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Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, et al.

TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids

Xiaoping Yang, Marco Delsante, Parnaz Daneshpajouhnejad, et al.

Discussion

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

McAlary L., Shephard V.K., Wright G.S.A., et al.

Developmental exposure to domoic acid disrupts startle response behavior and circuitry

Jennifer M. Panlilio, Ian T. Jones, Matthew C. Salanga, et al.

Investigating receptor-mediated antibody transcytosis using Blood-Brain Barrier organoid arrays

Claire Simonneau, Martina Duschmalé, Alina Gavrilov, et al.

Microtissue geometry and cell-generated forces drive patterning of liver progenitor cell differentiation in 3D

Ian C. Berg, Erfan Mohagheghian, Krista Habing, et al.

Discussion

A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule acetylation

Abhijit Deb Roy, Evan G. Gross, Gayatri S. Pillai, et al.

Discussion

Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection in Pre-Clinical Models

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, et al.

A High Content screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

Nataliia Serbyn, Ivona Bagdiul, Agnès H. Michel, et al.

Cardioids reveal self-organizing principles of human cardiogenesis

Pablo Hofbauer, Stefan Jahnel, Nora Papai, et al.

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion